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Nitrosamine Standards


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Nitrosamines are a class of chemical compounds that are known for their carcinogenic effects. They can be found as a contaminant in food, and pharmaceutical products. The accumulation of nitrosamines poses a major contamination risk to water resources such as drinking water, ground water, and wastewater. Our product line of nitrosamine standards includes a variety of both single and multi-component CRMs designed for determination of nitrosamine impurities in food and pharmaceuticals. Below, you can find products designed for FDA, ASTM, and EPA Methods.

Nitrosamines Categories

Use the links below to navigate to specific types of Nitrosamines.

Nitrosamines in Food and Pharmaceuticals
FDA Methods
ASTM Methods
EPA Methods
GB and HJ Methods
Nitrosamines in Toys

AccuStandard Nitrosamine Standards BrochureAccuStandard Nitrosamine Standards Brochure

Nitrosamines in Food and Pharmaceuticals

close up image of deli meat below blue and white pill capsules and tablets on blue background close up image of deli meat below blue and white pill capsules and tablets on blue background

As a “Process Contaminant”, N-nitrosamines form as a byproduct during the manufacturing of food and pharmaceuticals. Due to its known carcinogenic and genotoxic characteristics, selective analysis for different Nitrosamines is important to reduce consumer’s exposure to these toxic contaminants

FDA Methods - Nitrosamine Impurities in Drugs

  1. FDA-001S
    Nitrosamine Impurities in Drugs
    100 µg/mL in Methanol
    8 comps.

Nitrosamines Single Component Standards

  1. NAS-016S
    N-Nitroso fluoxetine
    100 µg/mL in Methanol
    Single
  2. NAS-017S
    N-Nitrosodicyclohexylamine
    100 µg/mL in Methanol
    Single
  3. NAS-018S
    N-Nitroso-N-methyl-4-aminobutyric acid
    100 µg/mL in Methanol
    Single
  4. NAS-019S
    N-Nitroso-ditertbutylamine
    100 µg/mL in Methanol
    Single
  5. NAS-020S
    N-Nitrosodiethanolamine (NDELA)
    100 µg/mL in Methanol
    Single
  6. NAS-021S
    1-Cyclopentyl-4-nitrosopiperazine (CPNP)
    100 µg/mL in Methanol
    Single
  7. NAS-022S
    1-Methyl-4-nitrosopiperazine (MNP)
    100 µg/mL in Methanol
    Single
  8. NAS-023S
    N-Nitrosodiisopropylamine (NDIPA)
    100 µg/mL in Methanol
    Single
  9. NAS-024S
    N-Nitroso-N-ethyl-2-propanamine (NEIPA)
    100 µg/mL in Methanol
    Single
  10. NAS-025S
    N-Nitrosodiisobutylamine (NDIBA)
    100 µg/mL in Methanol
    Single
  11. NAS-026S
    N-Nitrososarcosine (NSAR)
    100 µg/mL in Methanol
    Single
  12. NAS-027S
    N-Nitroso-N-methylaniline (NMPA)
    100 µg/mL in Methanol
    Single
  13. NAS-028S
    N-Nitrosodibenzylamine
    100 µg/mL in Methanol
    Single
  14. NAS-029S
    N-Nitrosodiisopropanolamine (NDIPLA)
    100 µg/mL in Methanol
    Single
  15. NAS-030S
    N'-Nitrosonornicotine (NNN)
    100 µg/mL in Methanol
    Single
  16. NAS-031S
    N-Methyl-N-nitroso-2-propanamine (NMIPA)
    100 µg/mLin Methanol
    Single
  17. NAS-033S
    N-Nitroso-N-methylbutylamine (MBNA)
    100 µg/mL in Methanol
    Single
  18. NAS-034S
    N,N'-bis(2-hydroxybenzylidene)-1,2-propanediamine
    100 µg/mL in Methanol
    Single
  19. NAS-035S
    N-Nitroso-1-(2-methoxyphenyl)piperazine
    100 µg/mL in Methanol
    Single
  20. NAS-036S
    4-Nitrosopiperazine-1-ethanol
    100 µg/mL in Methanol
    Single
  21. NEW! NAS-037S-CN
    4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    100 µg/mL in Acetonitrile
    Single
  22. NEW! NAS-038S
    N-Nitrosonortriptyline
    100 µg/mL in Methanol
    Single
  23. NEW! NAS-039S
    N-Methyl-N-nitroso-2-phenylethylamine (NMPEA)
    100 µg/mL in Methanol
    Single
  24. NEW! NAS-040S
    N-Nitroso Duloxetine
    100 µg/mL in Methanol
    Single
  25. NAS-D-001S
    N-Nitrosodi-n-propylamine-d14
    100 µg/mL in Methanol
    Single
  26. NAS-D-002S
    N-Nitrosodi-n-butylamine-d18
    100 µg/mL in Methanol
    Single
  27. NAS-D-003S
    N-Nitrosodiethylamine-d10
    100 µg/mL in Methanol
    Single
  28. NAS-D-004S
    N-Nitrosodimethylamine-d6
    100 µg/mL in Methanol
    Single
  29. NAS-D-020S
    N-Nitrosodiethanolamine-d8
    100 µg/mL in Methanol
    Single
  30. NAS-D-030S
    N'-Nitrosonornicotine-d4
    100 µg/mL in Methanol
    Single
  31. NEW! NAS-D-037S-CN
    4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-d4 (NNK-d4)
    100 µg/mL in Acetonitrile
    Single
  1. APP-9-147
    N-Nitrosodi-n-butylamine (NDBA)
    100 µg/mL in Dichloromethane
    Single
  2. APP-9-147-20X
    N-Nitrosodi-n-butylamine (NDBA)
    2.0 mg/mL in Dichloromethane
    Single
  3. APP-9-148
    N-Nitrosodiethylamine (NDEA)
    100 µg/mL in Dichloromethane
    Single
  4. APP-9-148-20X
    N-Nitrosodiethylamine (NDEA)
    2.0 mg/mL in Dichloromethane
    Single
  5. APP-9-149
    N-Nitrosodimethylamine (NDMA)
    100 µg/mL in Dichloromethane
    Single
  6. APP-9-149-M-10X
    N-Nitrosodimethylamine (NDMA)
    1000 µg/mL in MeOH
    Single
  7. APP-9-150
    N-Nitrosodiphenylamine
    100 µg/mL in Dichloromethane
    Single
  8. APP-9-150-M-10X
    N-Nitrosodiphenylamine
    1000 µg/mL in Methanol
    Single
  9. APP-9-151
    N-Nitrosodi-n-propylamine (NDPA)
    100 µg/mL in Dichloromethane
    Single
  10. APP-9-151-25X
    N-Nitrosodi-n-propylamine (NDPA)
    2.5 mg/mL in Dichloromethane
    Single
  11. APP-9-152
    N-Nitrosomethylethylamine
    100 µg/mL in Dichloromethane
    Single
  12. AS-E0060
    N-Nitrosodiphenylamine
    5.0 mg/mL in Methanol
    Single
  13. AS-E0061
    N-Nitrosodi-n-propylamine
    5.0 mg/mL in MeOH
    Single
  14. AS-E0334
    N-Nitrosodiethylamine (NDEA)
    5.0 mg/mL in MeOH
    Single
  15. AS-E0974
    N-Nitroso-N-methyl ethylamine
    1000 µg/mL in Methanol
    Single
  16. M-8015B-5031-20
    N-Nitrosodi-n-butylamine
    0.5 mg/mL in Water
    Single
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ASTM Methods

waste water treatment pond from industrial plantswaste water treatment pond from industrial plants

ASTM D8456 is designed to test for N-nitrosamines in groundwater, surface water, wastewater influents, and wastewater effluents.

ASTM D8456 Nitrosamines in Water

  1. D-8456
    Nitrosamines in Water
    2 µg/mL in Water:Methanol (98:2)
    13 comps.
  2. D-8456-IS
    Nitrosamines in Water (IS)
    2 µg/mL in Water:Methanol (98:2)
    2 comps.
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EPA Methods

close up of water pouring into glass on blue backgroundclose up of water pouring into glass on blue background

The USEPA has developed multiple test methods for the determination of Nitrosamines in drinking water, underground water and municipal & industrial wastewater. Monitoring contaminates such as NDMA, NDEA and other emerging nitrosamines is important for both regulation compliance as well as reducing exposure to these toxins.

EPA Method 521 - Nitrosamines in Drinking Water

  1. M-521
    EPA Method 521 Analyte Stock Solution
    200 µg/mL in methylene chloride
    7 comps.
  2. M-521-IS
    EPA Method 521 Internal Standard Stock Solution
    1000 µg/mL in Methylene chloride
    Single
  3. M-521-IS-PAK
    EPA Method 521 Internal Standard Stock Solution
    1000 µg/mL in Methylene chloride
    Single
  4. M-521-SS
    EPA Method 521 Surrogate Standard Stock Solution
    1000 µg/mL in Methylene chloride
    Single
  5. M-521-SS-PAK
    EPA Method 521 Surrogate Standard Stock Solution
    1000 µg/mL in Methylene chloride
    Single

EPA Method 607 - Nitrosamines in Wastewater

  1. M-607
    Nitrosamines Mix
    Varied conc. in MeOH
    3 comps.
  2. M-607-PAK
    Nitrosamines Mix
    Varied conc. in MeOH
    3 comps.

EPA Method 8070 - Detection of Nitrosamines by GC

  1. M-8070
    Nitrosamines
    2.0 mg/mL in MeOH
    3 comps.
  2. M-8070-PAK
    Nitrosamines
    2.0 mg/mL in MeOH
    3 comps.

EPA Method 8270 - Nitrosamines in Aqueous Matrices

  1. M-8270-01
    Semi-Volatile by Capillary Column GC/MS Mix 1
    2.0 mg/mL in CH2Cl2
    17 comps.
  2. M-8270-02
    Semi-Volatile by Capillary Column GC/MS Mix 2
    2.0 mg/mL in CH2Cl2
    18 comps.
  3. M-8270-02-R1
    Semi-Volatile by Capillary Column GC/MS Mix 2
    2 mg/mL in Dichloromethane
    17 comps.
  4. M-8270-03-ASL
    Method 8270B - Nitrosamines Mix
    2.0 mg/mL in CH2Cl2
    9 comps.
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GB and HJ Methods

GB Standards published by the Standardization Administration of ChinaGB Standards published by the Standardization Administration of China

Published by the Standardization Administration of China, GB Standards are designed to test for chemical contaminants and toxic chemicals according to the Chinese national standard. Our GB Nitrosamines CRMs are offered to allow for accurate and efficient analysis for these toxins.

GB/T 24153 - Nitrosamines in Rubber and Elastomers

  1. GBS-003S
    GB/T 24153 Nitrosamines Standard
    100 µg/mL in Methanol
    12 comps.

HJ 809 - Nitrosamines in Water Samples

  1. GBS-004S
    HJ 809 Nitrosamines Standard
    2000 µg/mL in Methanol
    9 comps.
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Nitrosamines in Toys

hand covered in paint red, blue, yellow, white, up close on blue backgroundhand covered in paint red, blue, yellow, white, up close on blue background

EN 71-12 was published to provide test method specifications to help reduce (N-NAs) exposure for children by quantifying traces of these dangerous toxins in toys such as finger paint and balloons.

Nitrosamines in Toys Reference Standard

  1. EN-7112
    Nitrosamines in Toys Reference Standard
    1000 µg/mL in Methanol
    13 comps.
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